Coumarins and derivatives
Cayman Chemical 7-EthoxycoumarIn 100mg
A CYP450 substrate; undergoes O-deethylation by various CYP isoforms; has been used in the functional characterization of CYPs in cats, rats, and isolated human cornea
AdipoGen Coumarin 334
Chemical. CAS 55804-67-6. Formula C17H17NO3. Molecular Weight 283.32. Coumarin 334 is a laser dye with an absorption maximum of 452nm. It is used as starting material for the synthesis of cysteine-selective or pH indicator fluorescent probes. Spectral data lambdamax 452nm, epsilon extinction coefficient >45000 at 449-455 nm in ethanol, lambdalaser 532nm.
eMolecules 185040-35-1 | 4-Ethylamino-2-methanethiopyrimidine-5-carboxaldehyde | 1g
Ambeed | 4-Fluoro-5-methoxy-1H-indole | 100mg | 561133591 | A355562 | 288385-89-7 | MFCD12924604 | 165.167 | C9H8FNO
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Medchemexpress LLC Coumarin (Standard) | 91-64-5 | 146.14 | 100 MG
Coumarin (Standard) is the analytical standard of Coumarin, intended for research and analytical applications. It is a potent, orally active anti-inflammatory agent, also exhibiting antinociceptive, antibacterial, antifungal, and anticancer activities.
This analytical standard is commonly used in qualitative, quantitative, and methodological research experiments such as HPLC, GC, and MS.
- Intended for research and analytical applications.
- Functions as an anti-inflammatory agent.
- Exhibits antinociceptive effects.
- Shows antibacterial activity.
- Displays antifungal activity.
- Demonstrates anticancer activity.
- Suitable for HPLC, GC, and MS research.
Medchemexpress LLC MTX-531 | 2791417-66-6 | 99.87% | 453.94 | 100 MG
MTX-531 is an oral drug that inhibits EGFR (with an IC50 of 14.7 nM) and PI3K (with IC50 values of 6.4, 233, 8.3, and 1.1 nM for PI3Kα, PI3Kβ, PI3Kγ, and PI3Kδ respectively), and it has anti-tumor effects. It also acts as a weak agonist of PPARγ, with an IC50 of 2.5 μM, helping to alleviate hyperglycemia induced by PI3K inhibitors.
- Shows a concentration-dependent inhibitory effect on EGFR, P13K, and mTOR in CAL-33 cells.
- Activates PPARγ in 3T3-L1 cells.
- Inhibits EGFR and PI3K-mTOR pathway signaling in a time-dependent manner in mice.
- Suppresses tumor proliferation in mice.
- Shows excellent tolerance in mice and uniquely does not cause the hyperglycemia commonly seen with PI3K inhibitors.
- Enhances MEK inhibition in CRC.
- Combined with KRAS-G12C inhibitors, it suppresses tumor growth in mice with KRAS-G12C mutant colorectal cancer or pancreatic tumors.
AdipoGen Coumarin 314
Chemical. CAS 55804-66-5. Formula C18H19NO4. Molecular Weight 313.35. Coumarin 314 is a rigidized aminocoumarin derivative used as a laser dye with an absorption maximum of 436nm. It can be used as starting material for the synthesis of fluorescent probes. Spectral data lambdamax 436nm in ethanol, epsilon extinction coefficient >39000 at 389-401 nm in ethanol, lambdalaser 504nm.
Medchemexpress LLC Coumarin-3-carboxylic acid | 531-81-7 | MFCD00006852 | 99.9% | 190.15 g/mol | C10H6O4 | 100 G
Coumarin-3-carboxylic acid is a coumarin derivative provided for research use as a white to off-white solid. It is used as a fluorescent probe for hydroxyl radicals and as a synthetic intermediate in coumarin chemistry. The material is offered in multiple package sizes to support analytical and preparative work.
- High purity suitable for research applications.
- Fluorescent probe for hydroxyl radical detection.
- Available in multiple package sizes including 100 g for scale-up.
- Solid white to off-white appearance, easy to weigh and store.
- Well-characterized chemical identifiers: CAS 531-81-7, C10H6O4.
Apexbio Technology LLC Coumarin-3-carboxylic Acid 531-81-7 200mg
Coumarin-3-carboxylic Acid is a coumarin-derived small molecule commonly applied as an investigative tool in biomedical research focusing on signal pathway regulation It is utilized to modulate enzymatic activities and cellular signaling pathways Coumarin-3-carboxylic Acid s biological activity has been studied in the context of its lanthanide complexes for inhibitory effects on cell growth in K-562 cell lines In cell-based studies it demonstrates antiproliferative activity in K-562 cells Based on these pharmacological properties Coumarin-3-carboxylic Acid holds research potential in elucidating biological mechanisms underlying hematologic malignancies and related diseases
Medchemexpress LLC 2H-1-Benzopyran-2-one, 6-bromo- | 19063-55-9 | 225.04 | 10 G
6-Bromocoumarin (6-Bromochromen-2-one) is a chemical compound identified as a potential anti-bacterial agent. It has been noted for not inhibiting 17β-HSD1 and for showing affinity for α and β estrogen receptors.
- Potential anti-bacterial agent
- Does not inhibit 17β-HSD1
- Shows affinity for α and β estrogen receptors
Apexbio Technology LLC 7-Amino-4-(trifluoromethyl)coumarin 53518-15-3 100mg
7-Amino-4-trifluoromethyl coumarin (CAS 53518-15-3) is a small-molecule antagonist targeting serotonin receptor subtype 1E (HTR1E) galanin receptor 2 (GALR2) and gamma receptor subtype 2 (GalR2) It is designed to antagonize these receptors thereby modulating receptor-mediated signaling pathways 7-Amino-4-trifluoromethyl coumarin exerts its biological activity primarily through receptor antagonism and inhibition of hydroxysteroid 17-beta dehydrogenase 4 (HSD17B4) enzymatic activity In biochemical assays it demonstrates inhibitory activity toward HSD17B4 with reported bioactivity at approximately 21 M Based on these pharmacological properties 7-Amino-4-trifluoromethyl coumarin holds research potential in the investigation of protease activity receptor-mediated signaling and metabolic enzyme regulation
Medchemexpress LLC 2-oxo-2H-1-benzopyran-3-carboxylic acid | 531-81-7 | MFCD00006852 | 99.9% | 190.15 g/mol | C10H6O4 | 50 G
Coumarin-3-carboxylic acid is a small-molecule research reagent (2-oxochromene-3-carboxylic acid) used as a fluorescent probe for hydroxyl radicals and as a synthetic building block. Supplied as a high-purity solid, it is suitable for in vitro studies and can be formulated for in vivo dosing when required.
Medchemexpress LLC 7-Hydroxycoumarin-3-carboxylic acid N-succinimidyl ester | 134471-24-2 | 50 MG
7-Hydroxycoumarin-3-carboxylic acid N-succinimidyl ester is the amine-reactive succinimidyl ester of 7-Hydroxycoumarin-3-carboxylic acid. It is a blue fluorescent dye used for labeling proteins and nucleic acids.
- Amine-reactive succinimidyl ester
- Blue fluorescent dye
- For labeling proteins
- For labeling nucleic acids
Cayman Chemical 7-EthoxycoumarIn 500mg
A CYP450 substrate; undergoes O-deethylation by various CYP isoforms; has been used in the functional characterization of CYPs in cats, rats, and isolated human cornea
Apexbio Technology LLC Psoralen,20mgCAS# 66-97-7
Psoralen is used as photochemical probe in studies of DNA mutation and repair mechanisms. Causes photosensitization in human. Other sizes are also available. Please inqury us for quote.